HUMAN PLACENTAL CHOLESTEROL SIDE-CHAIN CLEAVAGE - ENZYMATIC-SYNTHESISOF (22R)-20-ALPHA,22-DIHYDROXYCHOLESTEROL

Authors
TUCKEY RC CAMERON KJ
Citation
Rc. Tuckey et Kj. Cameron, HUMAN PLACENTAL CHOLESTEROL SIDE-CHAIN CLEAVAGE - ENZYMATIC-SYNTHESISOF (22R)-20-ALPHA,22-DIHYDROXYCHOLESTEROL, Steroids, 58(5), 1993, pp. 230-233
Citations number
14
Categorie Soggetti
Biology,"Endocrynology & Metabolism
Journal title
Steroids → ACNP
ISSN journal
0039128X
Volume
58
Issue
5
Year of publication
1993
Pages
230 - 233
Database
ISI
SICI code
0039-128X(1993)58:5<230:HPCSC->2.0.ZU;2-O
Abstract
(22R)-20alpha,22-Dihydroxycholesterol is the second intermediate in th e conversion of cholesterol to pregnenolone by cytochrome P450scc in s teroidogenic tissues. We report a rapid method for the enzymatic synth esis of (22R)-20alpha,22-dihydroxycholesterol from (22R)-22-hydroxycho lesterol using mitochondria from the human placenta.