IN-VITRO ANTIBACTERIAL ACTIVITY AND BETA-LACTAMASE STABILITY OF CP-70,429, A NEW PENEM ANTIBIOTIC

Authors
MINAMIMURA M TANIYAMA Y INOUE E MITSUHASHI S
Citation
M. Minamimura et al., IN-VITRO ANTIBACTERIAL ACTIVITY AND BETA-LACTAMASE STABILITY OF CP-70,429, A NEW PENEM ANTIBIOTIC, Antimicrobial agents and chemotherapy, 37(7), 1993, pp. 1547-1551
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
37
Issue
7
Year of publication
1993
Pages
1547 - 1551
Database
ISI
SICI code
0066-4804(1993)37:7<1547:IAAABS>2.0.ZU;2-Z
Abstract
In in vitro susceptibility tests, the new penem CP-70,429 showed poten t antibacterial activity against gram-positive and gram-negative bacte ria except Pseudomonas aeruginosa and Xanthomonas maltophilia. CP-70,4 29 was stable to various types of beta-lactamases except for the enzym e from X. maltophilia and was 16- to 128-fold more active than the oth er compounds against beta-lactamase-producing strains of Enterobacter cloacae and Citrobacter freundii.