OPTIMAL TREATMENT OF CANCER DISEASES

Authors
NOVAK A FEICHTINGER G
Citation
A. Novak et G. Feichtinger, OPTIMAL TREATMENT OF CANCER DISEASES, International Journal of Systems Science, 24(7), 1993, pp. 1253-1263
Citations number
15
Categorie Soggetti
System Science","Computer Applications & Cybernetics","Operatione Research & Management Science
Journal title
International Journal of Systems Science → ACNP
ISSN journal
00207721
Volume
24
Issue
7
Year of publication
1993
Pages
1253 - 1263
Database
ISI
SICI code
0020-7721(1993)24:7<1253:OTOCD>2.0.ZU;2-E
Abstract
A new optimal control model of chemotherapeutic cancer treatment is pr esented including both the number of cancer cells and the level of tox icity as state variables. It is shown that under certain conditions, p eriodic drug administration is optimal. Although the model is highly s tylized and too simple to describe realistic chemotherapeutic treatmen t patterns, it may be seen as a first step to prove that periodic trea tment strategies are superior to therapies with monotonic decreasing o r increasing dosage rates.