EASY AND GENERAL-METHOD FOR THE PREPARATION OF M-ACYLBENZOIC AND P-ACYLBENZOIC ACIDS - A NEW SYNTHESIS OF RAC-SUPROFEN

Authors
CAMPS P GIMENEZ S FARRES X MAULEON D CARGANICO G
Citation
P. Camps et al., EASY AND GENERAL-METHOD FOR THE PREPARATION OF M-ACYLBENZOIC AND P-ACYLBENZOIC ACIDS - A NEW SYNTHESIS OF RAC-SUPROFEN, Liebigs Annalen der Chemie, (6), 1993, pp. 641-643
Citations number
23
Categorie Soggetti
Chemistry
Journal title
Liebigs Annalen der Chemie → ACNP
ISSN journal
01702041
Issue
6
Year of publication
1993
Pages
641 - 643
Database
ISI
SICI code
0170-2041(1993):6<641:EAGFTP>2.0.ZU;2-F
Abstract
A method for the preparation of m- and p-acylbenzoic acids 3 based on the Claisen condensation of isophthalic or terephthalic diesters 1 wit h alpha-methylenecarboxylic esters 2 is described. p-Propionylbenzoic acid p-4 (R = Me) is used in a new synthesis of rac-suprofen (11).