DIABETES INCREASES EXCRETION OF URINARY MALONALDEHYDE CONJUGATES IN RATS

The effect of streptozotocin-induced diabetes on the urinary excretion of thiobarbituric acid test-positive materials was examined. In diabe tic rats, urinary excretion of thiobarbituric acid reactive substances was increased 5-fold over that in nondiabetic animals. High-performan ce liquid chromatography of urine samples revealed that five of the si x fractions previously found to be increased in vitamin E deficiency [ Lee, H.-S., Shoeman, D.W., and Csallany, A.S. (1992) Lipids 27, 124-12 8] were also significantly increased in streptozotocin-induced diabete s. The data suggest that a high level of oxidative stress is induced b y uncontrolled diabetes in rats.