As part of a project ''Music therapy in internal medicine'' we investi
gated 32 consecutive patients undergoing gastroscopy for various reaso
ns. Patients were randomly assigned to two groups, regardless of sex,
age or underlying disease. One groupe listened to music during gastros
copy, while the other did not. The choice of the type of music within
the corresponding group was made with the patient and a trained music
therapist in a short discussion prior to gastroscopy. The hormones ACT
H and cortisol, as well as the catecholamines adrenalin and noradrenal
in, were measured in both groups with three blood samples taken before
, directly after and one hour after gastroscopy. Parallel measurements
included blood pressure and pulse rate as well as questions about the
patients' feelings during gastroscopy. The study showed the rise in t
he plasma levels of the stress hormones ACTH and cortisol to be signif
icantly lower under the influence of music. The subjective feelings of
the patients concerning ''fear in general'' and ''fear about gastrosc
opy'' paralleled these findings. Conversely, the plasma adrenalin and
noradrenalin levels before and after gastroscopy were virtually unchan
ged in both groups, as were pulse rate and blood pressure. This study
shows the influence of music on human biochemical parameters when used
in the setting of a diagnostic procedure.