THE EVIDENCE OF THYROLIBERIN TRIIODOTHYRONIN CONTROL OF TSH SECRETORYRESPONSE FROM HUMAN PERIPHERAL-BLOOD MONOCYTES CULTURED IN-VITRO

Authors
KOMOROWSKI J STEPIEN H PAWLIKOWSKI M
Citation
J. Komorowski et al., THE EVIDENCE OF THYROLIBERIN TRIIODOTHYRONIN CONTROL OF TSH SECRETORYRESPONSE FROM HUMAN PERIPHERAL-BLOOD MONOCYTES CULTURED IN-VITRO, Neuropeptides, 25(1), 1993, pp. 31-34
Citations number
23
Categorie Soggetti
Neurosciences,"Endocrynology & Metabolism
Journal title
Neuropeptides → ACNP
ISSN journal
01434179
Volume
25
Issue
1
Year of publication
1993
Pages
31 - 34
Database
ISI
SICI code
0143-4179(1993)25:1<31:TEOTTC>2.0.ZU;2-K
Abstract
Immune system function has been shown to be under the influence of var ious neuromodulators and endocrine system peptides. This in vitro stud y describes the stimulatory effect of thyrotropin releasing hormone (t hyroliberin, TRH) on thyrotropin (TSH) release from cultured human per ipheral blood monocytes. The stimulatory effect of TRH on TSH release from monocytes is totally blocked by triiodothyronine (T3) administrat ions. These results indicate that TSH release from human monocytes is under the control of TRH/T3 mechanisms, similar to hypothalamic-pituit ary-thyroid axis.