J. Komorowski et al., THE EVIDENCE OF THYROLIBERIN TRIIODOTHYRONIN CONTROL OF TSH SECRETORYRESPONSE FROM HUMAN PERIPHERAL-BLOOD MONOCYTES CULTURED IN-VITRO, Neuropeptides, 25(1), 1993, pp. 31-34
Immune system function has been shown to be under the influence of var
ious neuromodulators and endocrine system peptides. This in vitro stud
y describes the stimulatory effect of thyrotropin releasing hormone (t
hyroliberin, TRH) on thyrotropin (TSH) release from cultured human per
ipheral blood monocytes. The stimulatory effect of TRH on TSH release
from monocytes is totally blocked by triiodothyronine (T3) administrat
ions. These results indicate that TSH release from human monocytes is
under the control of TRH/T3 mechanisms, similar to hypothalamic-pituit
ary-thyroid axis.