G. Zerekmelen et al., EFFECTS OF NEW SOMATOSTATIN ANALOGS ON THE CELL-PROLIFERATION OF COLONIC CRYPTS AND COLONIC CANCERS IN RATS, Neuropeptides, 25(1), 1993, pp. 57-60
The antiproliferative activity of two new somatostatin (SS) analogs: A
SS-51 and ASS-52 have been tested in this study. We assessed their abi
lity to inhibit the DNA synthesis in normal colon crypt cells and in t
he cells of chemically (dimethylhydrazine)-induced colon cancer in the
rats. The incorporation of bromodeoxyuridine (BrDU) into appropriate
cell nuclei was used as an index of DNA synthesis. It was found that:
1) Only ASS-51 significantly decreases the colon crypt cell proliferat
ion in the rat when compared to controls. Since both analogs were prev
iously shown to inhibit GH release, these data indicate that the antip
roliferogenic effect of ASS-51 is independent of the inhibition of GH
release. 2) Both examined analogs did not significantly effect the BrD
U incorporation into cell nuclei of chemically-induced colon cancer.