SYNTHESIS OF 2',3'-DIDEHYDRO-2',3'-DIDEOXY-2'-C- METHYLSUBSTITUTED NUCLEOSIDES USING A NOVEL SN2' TYPE REACTION

Authors
IONNIDIS P CLASSON B SAMUELSSON B KVARNSTROM I
Citation
P. Ionnidis et al., SYNTHESIS OF 2',3'-DIDEHYDRO-2',3'-DIDEOXY-2'-C- METHYLSUBSTITUTED NUCLEOSIDES USING A NOVEL SN2' TYPE REACTION, Nucleosides & nucleotides, 12(5), 1993, pp. 449-462
Citations number
18
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
12
Issue
5
Year of publication
1993
Pages
449 - 462
Database
ISI
SICI code
0732-8311(1993)12:5<449:SO2MN>2.0.ZU;2-6
Abstract
y-2-C-hydroxymethyl-beta-D-threo-pentofuranosyl)-, -2-C-hydroxymethyl- beta-D-glycero-pentofuranosyl)- and -2,3-dideoxy-beta-D-glycero-pentof uranosyl)uracil, thymine and cytosine were synthesized and evaluated f or their anti-HIV activities. A key step of the synthesis involves a n ovel alcohol transposition of 2-methylene-nucleoside analogues.