Gelatin capsules containing squalane partially purified bone morphogen
etic protein (BMP) complex were placed on the perimuscular membrane of
rats. Two kinds of control, gelatin capsules containing only BMP and
those bearing squalane only, were used. The embedded areas were histop
athologically examined at 3 and 6 wk after the operation. The observat
ions revealed that the squalane/BMP complex elicited wide heterotopic
bone formation with bone marrow tissue, suggesting that squalane is a
possible carrier of BMP for clinical applications.