THERMAL-ANALYSIS OF NANOPARTICLES OF POLY(ALKYLCYANOACRYLATE) AND QUANTITATIVE-EVALUATION OF THE CONSTITUENTS

The pharmaceutical industry is endeavouring to design vesicular colloi dal dosage forms able to carry the drug to the organ following adminis tration, without any degradation occuring. When this first step is sol ved it will be necessary to maintain constant release. Biodegradable p olymers such as dextrans, poly(d,l-lactide) or poly(alkylcyanoacrylate ) are able to play the part of surface active agents or suspending age nts (in drug adsorbancy), by making nanoparticles which are able to me et the two standards of carrying the drug and delivering it progressiv ely. Meanwhile the various molecular weights of dextrans used as suspe nding agents and their relative proportions can greatly modify the siz e, polydispersity index and encapsulation efficiency of the drug carri er. Using thermal methods we have studied the behaviour of the differe nt components of the ''white'' nanoparticle. We have also tried to est imate by thermogravimetric analysis the relative quantities of the nan oparticle components.