Nj. Reynolds et al., HYDRALAZINE PREDISPOSES TO ACUTE CUTANEOUS VASCULITIS FOLLOWING UROGRAPHY WITH IOPAMIDOL, British journal of dermatology, 129(1), 1993, pp. 82-85
We report a 60-year-old woman with renovascular hypertension who devel
oped a severe cutaneous vasculitis 24 h after the injection of iopamid
ol during urography. A review of the literature suggests that her conc
omitant hydrallazine therapy probably predisposed her to this reaction
, as similar reactions have occurred in systemic lupus erythematosus,
and hydrallazine can induce a LE-like syndrome. We recommend that urog
raphy should be avoided in patients receiving hydrallazine.