CLINICAL EFFECTIVENESS OF BRONCHO-VAXOM (BV) IN PATIENTS WITH CHRONICOBSTRUCTIVE PULMONARY-DISEASE

Sixty-two adult patients of both sexes with chronic obstructive pulmon ary disease (COPD) participated in a double-blind, placebo-controlled trial to determine the effects of treatment with Broncho-Vaxom (BV), a n immunomodulating agent, administered orally in capsule form. Clinica l manifestations, frequency, duration and severity of acute exacerbati ons, consumption of conventional medications and serum immunoglobulin levels were observed over a period of 6 months during the autumn/winte r of 1990-1991. Treatment with BV produced a statistically significant decrease, especially after the third month, in the mean score of the clinical signs, as well as in the cumulative index and in the number, severity and duration of acute exacerbations. In addition, a significa nt reduction in the use of conventional therapy was noticed.