RESEARCH ON NITROGEN-CONTAINING HETEROCYCLIC-COMPOUNDS .20. SYNTHESISOF H-IMIDAZO[5,1-C]PYRROLO-[1,2-A][1,4]BENZODIAZEPINE AND ITS 6-DERIVATIVES

Starting from 1H-1-(2-aminomethylphenyl)pyrrole the synthesis of H-imi dazo[5,1-c]pyrrolo[1,2-a][1,4]benzodiazepine, a novel nitrogen contain ing tetracyclic ring, has been performed by two routes involving a thr ee-step and a six-step sequence, respectively. The more complex sequen ce offers the advantage to obtain also 3-alkyl and 3-aryl derivatives of the parent nucleus. The three step sequence involves the use of tol uene-4-sulfonylmethylisocyanide (TosMIC) as a synthon.