STEREOSPECIFIC SYNTHESIS OF THE -ALPHA)-DECAHYDROBENZO[A]PYRROLO[3,2-G]QUINOLIZINE RING-SYSTEM

Authors
CLARK RD NELSON JT REPKE DB
Citation
Rd. Clark et al., STEREOSPECIFIC SYNTHESIS OF THE -ALPHA)-DECAHYDROBENZO[A]PYRROLO[3,2-G]QUINOLIZINE RING-SYSTEM, Journal of heterocyclic chemistry, 30(3), 1993, pp. 829-831
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
30
Issue
3
Year of publication
1993
Pages
829 - 831
Database
ISI
SICI code
0022-152X(1993)30:3<829:SSOT->2.0.ZU;2-Q
Abstract
A stereospecific synthesis of racemic thylsulfonyl)benzo[alpha]pyrrolo [3,2-g]quinolizine (2) is reported. Cyclocondensation of lithiated pyr rolecarboxamide 5 and dihydroisoquinoline 6 afforded the key tetracycl ic intermediate 7. Hydrogenation of 7 gave the 3aalpha 11balpha, 12aal pha-isomer 9 which was subsequently converted to 2.