A NOVEL SYNTHESIS OF HYDRO-2'-OXOFUR-3'-YL)-1H-PYRROLE-2-CARBOXALDEHYDE

Authors
HAYOZ P AEBY A PASQUIER C NEIER R
Citation
P. Hayoz et al., A NOVEL SYNTHESIS OF HYDRO-2'-OXOFUR-3'-YL)-1H-PYRROLE-2-CARBOXALDEHYDE, Chimia, 47(6), 1993, pp. 230-232
Citations number
16
Categorie Soggetti
Chemistry
Journal title
Chimia → ACNP
ISSN journal
00094293
Volume
47
Issue
6
Year of publication
1993
Pages
230 - 232
Database
ISI
SICI code
0009-4293(1993)47:6<230:ANSOH>2.0.ZU;2-E
Abstract
A novel six-step synthesis of ydro-2'-oxo-fur-3'-yl)-1H-pyrrole-2-carb oxaldehyde (rac-1) starting from 2-methylfuran has been developed. The key step is the formation of 2-methyl-1-(tetrahydro-2'-oxofur-3'-yl)- 1H-pyrrole (rac-7) according to the Clauson-Kaas procedure. Subsequent Vilsmeier formylation, oxidation with lead tetraacetate, and enzymati c hydrolysis led to rac-1.