PREPARATION OF [CYS(2)]-RA-VII - THE 1ST SULFUR-CONTAINING ANALOG OF RAS POSSESSING ANTITUMOR-ACTIVITY - STUDIES ON RA DERIVATIVES .3.

Authors
ITOKAWA H KONDO K HITOTSUYANAGI Y TAKEYA K
Citation
H. Itokawa et al., PREPARATION OF [CYS(2)]-RA-VII - THE 1ST SULFUR-CONTAINING ANALOG OF RAS POSSESSING ANTITUMOR-ACTIVITY - STUDIES ON RA DERIVATIVES .3., Heterocycles, 36(8), 1993, pp. 1837-1843
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
36
Issue
8
Year of publication
1993
Pages
1837 - 1843
Database
ISI
SICI code
0385-5414(1993)36:8<1837:PO[-T1>2.0.ZU;2-K
Abstract
RA-III (2), a potent antitumor cyclic hexapeptide, has been converted to [Cys2]-RA-VII (5) via thiolacetate (3). Derivatives (3) and (5) sho wed antitumor activities against P388 leukemia cells in vitro and in v ivo.