The upper respiratory mucosa has been reported to react to sex hormone
s in both physiological and pathological conditions. The present study
was specifically aimed to determine the influence of high levels of o
estrogen on Eustachian tube function. Fifty-three healthy, pregnant wo
men were prospectively evaluated for Eustachian tube function during p
regnancy. Eustachian tube function was found to be highly variable in
different women, and in the same woman at different stages of pregnanc
y. We did not find a specific trend in Eustachian tube function with i
ncreasing oestrogen levels as encountered during pregnancy.