HIGH-DOSE CYTARABINE NEUROTOXICITY - MR FINDINGS DURING THE ACUTE-PHASE

The authors report an acute cerebral and cerebellar syndrome in a pati ent treated with high-dose cytarabine. Diffuse high-intensity lesions in the central white matter on T2-weighted MR completely reversed with resolution of the clinical syndrome. Although the autopsy revealed ce rebellar injury, the cerebral cortex was grossly and microscopically n ormal, consistent with a reversible process.