LOW-PREVALENCE OF HUMAN PAPILLOMAVIRUS TYPE-16 AND TYPE-18 IN CERVICAL ADENOCARCINOMA IN-SITU, INVASIVE ADENOCARCINOMA, AND GLANDULAR DYSPLASIA BY POLYMERASE CHAIN-REACTION

Using the polymerase chain reaction on paraffin blocks for human papil lomavirus (HPV) types 16 and 18, a positive result was seen in three o f 20 cases of invasive adenocarcinoma, 15 of 36 cases of adenocarcinom a in-situ, and one of five cases of glandular dysplasia of the uterine cervix. Types 16 and 18 were found with equal frequency. In adenocarc inoma in situ there was no age difference between HPV-positive and or HPV-negative cases. Concomitant squamous dysplasia was slightly more f requent in HPV-positive adenocarcinoma in-situ. HPV positivity rates a re lower than most of those previously reported. Possible reasons for this are discussed.