DEMONSTRATION OF COEXISTENT B-CELL LYMPHOMA AND THERAPY-RELATED ACUTEMYELOGENOUS LEUKEMIA IN LYMPH-NODES BY FLOW-CYTOMETRY AND IMMUNOHISTOCHEMISTRY - CASE-REPORT AND REVIEW OF THE LITERATURE

A 58-yr-old white woman, with a 9-yr history of non-Hodgkin's lymphoma with recurrences and multi-modality therapy, presents with acute leuk emia and residual lymphadenopathy. By flow cytometric analysis, cytoch emistry, and cytomorphology, the leukemia is classified as acute myelo genous leukemia (AML), M4, and the lymph nodes are found to contain re sidual NHL in addition to an AML infiltrate. Immunohistochemistry perf ormed on the lymph nodes correlates with the flow cytometric data. A r eview of the literature of AML secondary to therapy for non-Hodgkin's lymphoma is also conducted. There are no documented cases in the Engli sh literature of simultaneous involvement of lymph nodes by residual l ymphoma and an AML infiltrate. Thus, this report is unique in the simu ltaneous involvement of lymph nodes by residual lymphoma and therapy-r elated AML. It emphasizes the application and usefulness of flow cytom etry and immunohistochemistry in such cases.