COBALT-MESOPORPHYRIN INHIBITS HEME OXYGENASE ACTIVITY BUT IT DOES NOTINDUCE LIPID-PEROXIDATION IN RAT-BRAIN MEMBRANES DURING PHOTOIRRADIATION

Authors
KEINO H BANNO T MIMURA S KASHIWAMATA S
Citation
H. Keino et al., COBALT-MESOPORPHYRIN INHIBITS HEME OXYGENASE ACTIVITY BUT IT DOES NOTINDUCE LIPID-PEROXIDATION IN RAT-BRAIN MEMBRANES DURING PHOTOIRRADIATION, Biology of the neonate, 63(5), 1993, pp. 285-289
Citations number
17
Categorie Soggetti
Pediatrics
Journal title
Biology of the neonate → ACNP
ISSN journal
00063126
Volume
63
Issue
5
Year of publication
1993
Pages
285 - 289
Database
ISI
SICI code
0006-3126(1993)63:5<285:CIHOAB>2.0.ZU;2-K
Abstract
We examined the effects of cobalt-mesoporphyrin (CoMP) in vitro. The p orphyrin inhibited the activity of rat splenic heme oxygenase but scar cely stimulated peroxidation of lipids in a membrane fraction from rat brain during photoirradiation. The apparent inhibition constant for C oMP was 344 nM. It is suggested that CoMP may be a promising candidate for a chemopreventive of neonatal hyperbilirubinemia that is not asso ciated with phototoxicity.