EPILEPSY IN DOWN-SYNDROME - CLINICAL ASPECTS AND POSSIBLE MECHANISMS

Although epilepsy is more common in persons with trisomy 21 (Down synd rome) than in the general population, the mechanisms by which seizures are generated in this population have received little attention. It i s likely that this increased seizure susceptibility is due to a combin ation of medical risk factors and inherent neurologic abnormalities ch aracteristic of Down syndrome. In this review clinical aspects of seiz ures among individuals with Down syndrome were described and possible mechanisms by which the trisomy 21 brain may generate seizures were ex plored.