We review some of our recent work on the analysis of DNA extracted fro
m skeletal remains up to four thousand years old, which is made possib
le by the exquisite sensitivity of the polymerase chain reaction. To d
o this, we consider in some detail our approach to a particular archae
ological problem, the question of the scale and nature of the settleme
nts which took place in post-Roman Britain. This involves the analysis
of the mitochondrial DNA control region surviving in bone material fr
om early Anglo-Saxon cemeteries, and from likely modern descendents of
the British and Germanic populations. We discuss the potential value
and limitations of such an approach, and in so doing give some indicat
ion of the present state of the art.