The widespread belief that the development of modern science and techn
ology since the Renaissance is responsible for anthropogenic global cl
imate change has important ideological overtones as it underestimates
the fundamental idiosyncrasy of cultural organization. Large-scale ant
hropogenic disturbance of the natural order began in prehistoric times
, probably more than a million years ago, and the domestication of fir
e was the major cause of this change. Early systematic burning has amp
lified the savanna landscape, particularly in Africa, and large-scale
climatic change is a likely result. Recent estimates suggest that the
age of Homo, of the first stone tools and of the shift to cooler and d
rier conditions at the beginning of the Pleistocene, virtually coincid
e at 2.4 to 2.5 Ma. We raise the hypothesis that this was also the age
of fire domestication, causing large-scale amplification of the savan
na landscape. We propose that this early human interference may have b
een an important factor leading to the climate destabilization charact
eristic of the Pleistocene. We indicate that African Lake deposits as
well as the deep sea sedimentary record around the affected continents
, e.g. in the Angola Basin, provide a more reliable record of early an
thropogenic global change than the continental sediments. Dedicated st
ratigraphical research of the former deposits, using biomolecular arch
aeological approaches, is likely to provide the evidence by which our
hypothesis may be falsified. We particularly advocate the use of immun
ological techniques as they reveal macromolecular structure rather tha
n sheer composition.