Objectives-To investigate whether childhood cancer is associated with
intramuscular administration of vitamin K to newborn infants. Design-R
outines for administration of vitamin K to infants born after normal d
eliveries during 1973-89 were obtained from maternity hospitals. Occur
rence of cancer up to the end of 1991 was identified by comparing thes
e records with the national cancer registry. Adherence to the routine
method of administering vitamin K was checked with the medical records
of a sample of 396 infants (196 who had developed childhood cancer an
d 200 controls). Setting-All maternity hospitals in Sweden. Subjects-1
384 424 full term infants born after non-instrumental deliveries, 1 0
85 654 of whom were born in units where vitamin K was routinely given
by intramuscular injection and 272 080 of whom were born where it was
given orally. Main outcome measures-Odds ratios for cancer after intra
muscular administration of vitamin K versus oral administration after
stratification for year of birth. Results-Adherence to routine method
of administering vitamin K was 92% in the 235 cases where individual i
nformation could be found. The risk of cancer after intramuscular admi
nistration of vitamim K was not elevated compared with that after oral
administration: odds ratios of 1.01 (95% confidence interval 0.88 to
1.17) for all childhood cancers and 0.90 (0.70 to 1.16) for childhood
leukaemia. Conclusions-The alleged association between intramuscular v
itamin K prophylaxis to newborn infants and childhood cancer could not
be verified in the present study of full term infants born after non-
instrumental delivery.