DIFFERENTIAL-PULSE VOLTAMMETRIC DETERMINATION OF 7-HYDROXYCOUMARIN INHUMAN URINE

Authors
DEMPSEY E OSULLIVAN C SMYTH MR EGAN D OKENNEDY R WANG J
Citation
E. Dempsey et al., DIFFERENTIAL-PULSE VOLTAMMETRIC DETERMINATION OF 7-HYDROXYCOUMARIN INHUMAN URINE, Journal of pharmaceutical and biomedical analysis, 11(6), 1993, pp. 443-446
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
11
Issue
6
Year of publication
1993
Pages
443 - 446
Database
ISI
SICI code
0731-7085(1993)11:6<443:DVDO7I>2.0.ZU;2-V
Abstract
The electrochemical behaviour of 7-OH-coumarin at the bare glassy carb on electrode has been studied using differential pulse voltammetry, an d based on anodic detection of this metabolite at 0.66 V (vs SCE) usin g DC amperometry, a method has been developed for the determination of 7-OH-coumarin levels in urine samples, and a pharmacokinetic profile established.