2',3'-DIDEOXYINOSINE (DDI) - ITS CHEMICAL-STABILITY AND CYCLODEXTRIN COMPLEXATION IN AQUEOUS-MEDIA

Authors
BEKERS O BEIJNEN JH TANK MJTK BURGER DM MEENHORST PL LOMBARTS AJPF UNDERBERG WJM
Citation
O. Bekers et al., 2',3'-DIDEOXYINOSINE (DDI) - ITS CHEMICAL-STABILITY AND CYCLODEXTRIN COMPLEXATION IN AQUEOUS-MEDIA, Journal of pharmaceutical and biomedical analysis, 11(6), 1993, pp. 489-493
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
11
Issue
6
Year of publication
1993
Pages
489 - 493
Database
ISI
SICI code
0731-7085(1993)11:6<489:2(-ICA>2.0.ZU;2-N
Abstract
The chemical stability of 2',3'-dideoxyinosine has been studied over a wide pH range (0-12). A stability-indicating HPLC method was used to separate the degradation product from the parent drug. The effects of temperature, ionic strength and buffer components on the degradation k inetics were investigated. Furthermore, the influence of some cyclodex trins (alpha-, beta-, HP-beta-, DM-beta- and gamma-cyclodextrin) on th e drug stability have been studied.