Tolosa Hunt syndrome (THS) is a painful ophthalmoplegia due to a nonsp
ecific inflammatory process in the cavernous sinus or to parasellar ne
oplasms. Although the cause of the disease is unknown, previous observ
ations support the hypothesis that THS may be only one manifestation o
f a generalized vasculitis. The diagnosis is based on findings of pain
ful ophthalmoplegia, excellent response to corticosteroids, and exclus
ion of other causes including aneurysm, diabetes mellitus, paranasal m
ucocele, and carotid cavernous fistula. We report the case of a 24-yea
r-old woman with THS who had undergone thyroidectomy 4 years before ad
mission for goiter with histologic diagnosis of Hashimoto's thyroiditi
s. This case shows the unusual association between Hashimoto's thyroid
itis and THS and supports the autoimmune origin of both diseases.