M. Haraphongse et al., LONG-TERM CLINICAL OUTCOMES FOLLOWING ISOLATED MITRAL-VALVE REPLACEMENT, Canadian journal of cardiology, 9(5), 1993, pp. 417-422
OBJECTIVE: This study reviews the short and long term outcomes of pati
ents who underwent isolated mitral valve replacement at the University
of Alberta Hospitals during the past decade. DESIGN: Data were obtain
ed retrospectively by review of patients' hospital charts, cardiologis
ts' follow-up charts, contact with patients' physicians, and direct te
lephone or mail contact with patients and/or their surviving relatives
. RESULTS: The clinical outcomes of 198 consecutive patients (124 wome
n and 74 men) who underwent isolated mitral valve replacement from Jan
uary 1981 to December 1990 at the University of Alberta Hospital were
reviewed. Overall early operative mortality was 11%. Deaths were mainl
y related to pump failure and previous mitral valve replacement. Late
mortality was 17%. Follow-up data were available except in five patien
ts. Average follow-up was 6.3 years. Overall cumulative survival was 7
2.9 +/- 3.4% at five years and 63.1 +/- 4.8% at 10 years. The cumulati
ve freedom from complications was 64.3 +/- 3.9% and 36.4 +/- 4.9% at f
ive and 10 years, respectively. Long term survival rates obtained afte
r isolated mitral valve replacement are higher than those reported in
series of medically treated patients with mitral valve disease. CONCLU
SIONS. Mitral valve replacement can prolong survival as well as improv
e symptoms in patients with symptomatic mitral valve disease.