Paradoxical embolism-in-transit is an uncommon presentation of the thr
omboembolism complex. The advent of echocardiography has permitted its
antemortem diagnosis and serves to guide treatment; this is illustrat
ed by the case of a 51-year-old female who presented with paradoxical
embolism-in-transit and pulmonary embolism following craniotomy. Echoc
ardiography demonstrated mobile clot straddling the atrial septum and
embolus in the right pulmonary artery. Surgery successfully removed al
l clots as demonstrated by intraoperative echocardiography, and the pa
tient had an uneventful recovery.