AN EPIDEMIOLOGIC-STUDY OF ISOLATED SPLIT HAND FOOT IN HUNGARY, 1975-1984

A population based and validated 10 year cohort of 94 cases with split hand/foot born in Hungary, 1975-1984 was evaluated. This type of cong enital limb deficiency was relatively frequently (43%) associated with non-limb defects. Fifty-four cases with isolated split hand/foot are evaluated in this paper. A single limb was affected in 78% of cases. T he upper limbs were 21 times more frequently affected in unimelic case s with a right sided predominance and male excess. Case-control analys is indicated intrauterine growth retardation and lower socioeconomic s tatus of parents of cases. Family study showed six familial cases with autosomal dominant inheritance among 152 first and 452 second degree relatives. All familial cases were males.