DIRECTED 2-METALATION OF N,N-DIETHYL O-3-(4-TRIMETHYLSILYL)PYRIDYL CARBAMATE - A SILICON PROTECTION ROUTE FOR HIGHLY SUBSTITUTED PYRIDINES

Authors
TSUKAZAKI M SNIECKUS V
Citation
M. Tsukazaki et V. Snieckus, DIRECTED 2-METALATION OF N,N-DIETHYL O-3-(4-TRIMETHYLSILYL)PYRIDYL CARBAMATE - A SILICON PROTECTION ROUTE FOR HIGHLY SUBSTITUTED PYRIDINES, Heterocycles, 35(2), 1993, pp. 689-692
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
35
Issue
2
Year of publication
1993
Pages
689 - 692
Database
ISI
SICI code
0385-5414(1993)35:2<689:D2ONOC>2.0.ZU;2-U
Abstract
LiTMP metalation of N,N-diethyl O-3-(4-trimethylsilyl)pyridyl carbamat e (4) followed by quenching with a number of carbon and heteroatom ele ctrophiles affords a variety of 2-substituted derivatives (5) (Table 2 ) thus providing a versatile new methodology for the synthesis of poly substituted pyridines.