EFFICIENT MICHAEL ADDITION-REACTIONS OF THE N-ARYLSULFONYL-3-PHENYLTHIOPIPERIDONES - SYNTHESIS OF 3-SUBSTITUTED DIHYDROPYRIDINONES

Authors
NAKAGAWA M TORISAWA Y HOSAKA T TANABE K TAVET F AIKAWA M HINO T
Citation
M. Nakagawa et al., EFFICIENT MICHAEL ADDITION-REACTIONS OF THE N-ARYLSULFONYL-3-PHENYLTHIOPIPERIDONES - SYNTHESIS OF 3-SUBSTITUTED DIHYDROPYRIDINONES, Heterocycles, 35(2), 1993, pp. 1157-1170
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
35
Issue
2
Year of publication
1993
Pages
1157 - 1170
Database
ISI
SICI code
0385-5414(1993)35:2<1157:EMAOTN>2.0.ZU;2-J
Abstract
Efficient methods for the Michael addition reactions of N-arylsulfonyl -3-phenylthiopiperidones (1) with both the protected amidoacrylates (4 , 9) and the simple acrylates (12) have been developed. These reaction s offer an efficient route to the 3-alkyl-substituted dihydropyridinon es (3, 11), the dienophiles employed in the natural product synthesis.