Background. Synovial sarcoma usually arises in the extremities and in
close proximity to large joints. Reported examples arising in the ante
rior abdominal wall are rare. Because most accounts from this location
consist of case reports, neither clinical nor prognostic features hav
e been well delineated. Methods. Twenty-seven synovial sarcomas of the
abdominal wall (SSAW), retrieved from the Soft Tissue Registry of the
Armed Forces Institute of Pathology, were reviewed and analyzed retro
spectively. Immunohistochemical stains were performed in 18 cases. Res
ults. There were specimens from 12 male and 15 female patients, rangin
g in age from 8 to 58 years (median, 23 years). The tumors were classi
fied as biphasic (14), predominantly monophasic fibrous (8), and poorl
y differentiated (5) types. The neoplasms occasionally were cystic and
typically reacted, at least focally, with antibodies directed against
keratin and/or epithelial membrane antigen. Eight tumors were smaller
than 5 cm.; 17 tumors were 5 cm or larger in size. Dimensions were no
t recorded in two cases. Follow-up, ranging from 1 to 264 months, was
obtained in 18 cases. Nine individuals were alive and well and eight w
ere dead of disease at median follow-up intervals of 98 and 26 months,
respectively. One patient was dead with disease, possibly secondary t
o chemotherapy-related causes. All nine patients who have died had cli
nical evidence of metastatic disease. Patients who presented with tumo
rs 5 cm or larger had a less favorable outcome than whose with tumors
smaller than 5 cm. (58% versus 40% mortality). A positive correlation
was noted between increased mitotic activity and the mortality rate. A
lthough patients with biphasic and predominantly monophasic fibrous tu
mors had a similar mortality rate (40% for both groups), patients with
poorly differentiated synovial sarcoma fared worse (100% mortality).
In general, poorly differentiated synovial sarcomas had a higher mitot
ic rate than either biphasic or monophasic fibrous examples. No apprec
iable difference in survival was evident based on the age at presentat
ion (< 15 versus greater-than-or-equal-to 15 years of age). Conclusion
s. The survival rate for patients with SSAW is similar to that reporte
d for synovial sarcoma in general. A high mitotic rate and the poorly
differentiated subtype of synovial sarcoma both were associated with a
poor prognosis and, to some extent, appear interrelated. Less favorab
le behavior also was noted when the tumors were large (greater-than-or
equal-to 5 cm). Pluripotential or arthrogenous mesenchyme may be impl
icated in the pathogenesis of these tumors.