DIRECT SELECTION OF ANTIBODIES THAT COORDINATE METALS FROM SEMISYNTHETIC COMBINATORIAL LIBRARIES

Authors
BARBAS CF ROSENBLUM JS LERNER RA
Citation
Cf. Barbas et al., DIRECT SELECTION OF ANTIBODIES THAT COORDINATE METALS FROM SEMISYNTHETIC COMBINATORIAL LIBRARIES, Proceedings of the National Academy of Sciences of the United Statesof America, 90(14), 1993, pp. 6385-6389
Citations number
29
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
90
Issue
14
Year of publication
1993
Pages
6385 - 6389
Database
ISI
SICI code
0027-8424(1993)90:14<6385:DSOATC>2.0.ZU;2-K
Abstract
An iterative strategy for the selection of catalytic metalloantibodies is described. The first stage of this strategy is validated by the se lection of semisynthetic antibodies that coordinate a variety of diffe rent metal ions and the metal oxide magnetite. These results have impl ications not only for the development of catalytic metalloantibodies b ut also for the development of reagents for magnetic resonance imaging , delivery of radioisotopes, and purification of recombinant proteins.