NEURONAL COLOCALIZATION OF MESSENGER-RNAS FOR NEUROTROPHINS AND THEIRRECEPTORS IN THE DEVELOPING CENTRAL-NERVOUS-SYSTEM SUGGESTS A POTENTIAL FOR AUTOCRINE INTERACTIONS
Rc. Miranda et al., NEURONAL COLOCALIZATION OF MESSENGER-RNAS FOR NEUROTROPHINS AND THEIRRECEPTORS IN THE DEVELOPING CENTRAL-NERVOUS-SYSTEM SUGGESTS A POTENTIAL FOR AUTOCRINE INTERACTIONS, Proceedings of the National Academy of Sciences of the United Statesof America, 90(14), 1993, pp. 6439-6443
Development and survival of neurons in the central nervous system are
dependent on the activity of a variety of endogenous neurotrophic agen
ts. Using combined isotopic and nonisotopic in situ hybridization hist
ochemistry, we have found that subsets of neurons within the developin
g forebrain coexpress the mRNAs for both neurotrophins (nerve growth f
actor, brain-derived neurotrophic factor, and neurotrophic 3) and thei
r receptors (p75NGFR, TrkA, and TrkB). The colocalization of mRNA for
neurotrophic receptors and their ligands in presumptive neurotrophic t
arget neurons suggests the potential for autocrine and paracrine mecha
nisms of action during development. Such mechanisms may ensure the ons
et of differentiation and survival of specific subsets of neurons prio
r to and following target innervation.