SYNTHESIS OF DIAMINODIDEOXYALDITOL ANALOGS OF CISPLATIN AS ANTITUMOR AGENTS

Authors
HANESSIAN S GAUTHIER JY OKAMOTO K BEAUCHAMP AL THEOPHANIDES T
Citation
S. Hanessian et al., SYNTHESIS OF DIAMINODIDEOXYALDITOL ANALOGS OF CISPLATIN AS ANTITUMOR AGENTS, Canadian journal of chemistry, 71(6), 1993, pp. 880-885
Citations number
32
Categorie Soggetti
Chemistry
Journal title
Canadian journal of chemistry → ACNP
ISSN journal
00084042
Volume
71
Issue
6
Year of publication
1993
Pages
880 - 885
Database
ISI
SICI code
0008-4042(1993)71:6<880:SODAOC>2.0.ZU;2-2
Abstract
Acyclic vicinal polyol complexes related to cisplatin were synthesized from D-mannitol by stereocontrolled manipulation of the hydroxy group s. Controlled cleavage of a 3,4-diazido hexitol gave the corresponding D-threitol and D-Xylitol analogs, which were converted to their diami no platinum complexes. The antitumor activity of these compounds is re ported.