HEMOLYTIC-UREMIC SYNDROME AFTER BONE-MARROW TRANSPLANTATION WITHOUT TOTAL-BODY IRRADIATION

The cause of hemolytic uremic syndrome after bone marrow transplantati on is unknown. Investigators have implicated multiple causes, includin g cyclosporin A, graft versus host disease, cytomegalovirus infection, and total body irradiation. We report a case of biopsy-supported hemo lytic uremic syndrome in a recipient of an autologous bone marrow tran splant who did not receive total body irradiation or cyclosporin A and did not have clinical evidence of cytomegalovirus infection. This cas e casts doubt on the hypothesis that irradiation or any of these facto rs is the sole and universal cause of hemolytic uremic syndrome in pat ients receiving bone marrow transplants.