BIDIRECTIONAL CYTOKINE INTERACTIONS IN THE MATERNAL-FETAL RELATIONSHIP - IS SUCCESSFUL PREGNANCY A TH2 PHENOMENON

Authors
WEGMANN TG LIN H GUILBERT L MOSMANN TR
Citation
Tg. Wegmann et al., BIDIRECTIONAL CYTOKINE INTERACTIONS IN THE MATERNAL-FETAL RELATIONSHIP - IS SUCCESSFUL PREGNANCY A TH2 PHENOMENON, Immunology today, 14(7), 1993, pp. 353-356
Citations number
39
Categorie Soggetti
Immunology
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
14
Issue
7
Year of publication
1993
Pages
353 - 356
Database
ISI
SICI code
0167-5699(1993)14:7<353:BCIITM>2.0.ZU;2-G
Abstract
Pregnant females are susceptible to intracellular pathogens and are bi ased towards humoral rather than cell-mediated immunity. Since T(H)1 c ytokines compromise pregnancy and T(H)2 cytokines are produced at the maternal-fetal interface, we hypothesize that these T(H)2 cytokines in hibit T(H)1 responses, improving fetal survival but impairing response s against some pathogens.