INTERLEUKIN-11 INDUCES RAPID PKC ACTIVATION AND CYTOSOLIC TO PARTICULATE TRANSLOCATION OF ALPHA-PKC AND BETA-PKC ISOFORMS IN HUMAN ERYTHROLEUKEMIA K562 CELLS
Gc. Spencer et Se. Adunyah, INTERLEUKIN-11 INDUCES RAPID PKC ACTIVATION AND CYTOSOLIC TO PARTICULATE TRANSLOCATION OF ALPHA-PKC AND BETA-PKC ISOFORMS IN HUMAN ERYTHROLEUKEMIA K562 CELLS, Biochemical and biophysical research communications, 232(1), 1997, pp. 61-64
Interleukin-11 (IL-11) is a pleiotropic cytokine which regulates the g
rowth of hematopoietic progenitor cells and activates platelet maturat
ion. Previous studies have shown that, IL-11 activates a set of signal
ing cascades involving the JAK/STAT and Raf/MAPK pathways. The purpose
of the current studies was to obtain evidence about the possible invo
lvement of PKC in the IL-11 signaling pathway. Evidence presented in t
his report suggests that IL-11 stimulates rapid PKC activation and mar
kedly induces cytosolic to particulate (membrane) association of alpha
and beta PKC isoforms. These findings provide preliminary evidence th
at PKC may be involved in the IL-11 signaling cascade. (C) 1997 Academ
ic Press.