PHARMACOKINETICS AND RELATIVE BIOAVAILABILITY OF NIMODIPINE CAPSULES AND TABLETS IN 8 CHINESE HEALTHY-MEN

A single oral dose of tablets or capsules of 239 mumol nimodipine was given to 8 healthy volunteers of Han nationality in a randomized cross over study. Plasma levels were determined with HPLC method. The plasma concentration-time curve fitted to a first order absorption , 1 - com partment open model, and the T1/2K was around 2 h. Although the capsul es could reach peak level faster, the bioavailability was not signific antly different from that of the tablets.