PROTECTIVE EFFECTS OF 3, 6-DIMETHAMIDODIB ENZOPYR-IODONIUM CITRATE ONMYOCARDIAL INJURY-INDUCED BY ISCHEMIA AND REPERFUSION IN RATS

Authors
DENG XL QIU PL LIU JT CHEN SY
Citation
Xl. Deng et al., PROTECTIVE EFFECTS OF 3, 6-DIMETHAMIDODIB ENZOPYR-IODONIUM CITRATE ONMYOCARDIAL INJURY-INDUCED BY ISCHEMIA AND REPERFUSION IN RATS, Zhongguo yaoli xuebao, 14(4), 1993, pp. 367-369
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Zhongguo yaoli xuebao → ACNP
ISSN journal
02539756
Volume
14
Issue
4
Year of publication
1993
Pages
367 - 369
Database
ISI
SICI code
0253-9756(1993)14:4<367:PEO36E>2.0.ZU;2-G
Abstract
3, 6-Dimethamidodibenzopyriodonium citrate (I-65) 0.5 and 1 mg . kg-1 pretreatment reduced the size of myocardial infarct after ischemia for 40 min and reperfusion for 120 min. I-65 0.5 mg . kg-1 decreased myoc ardial creatine kinase, lactate dehydrogenase release, and Ca2+ accumu lation after ischemia for 40 min and reperfusion for 120 min. The resu lts show that I-65 prevents cardiac ischemia and reperfusion injury an d the effect is considered to be related to inhibition of myocardial C a2+ accumulation.