FORMATION OF PYROGLUTAMYLGLUTAMINE (OR ASPARAGINE) DIKETOPIPERAZINE IN NONCLASSICAL CONDITIONS - A SIDE REACTION IN PEPTIDE-SYNTHESIS

Authors
MAZUROV AA ANDRONATI SA KOROTENKO TI GORBATYUK VY SHAPIRO YE
Citation
Aa. Mazurov et al., FORMATION OF PYROGLUTAMYLGLUTAMINE (OR ASPARAGINE) DIKETOPIPERAZINE IN NONCLASSICAL CONDITIONS - A SIDE REACTION IN PEPTIDE-SYNTHESIS, International journal of peptide & protein research, 42(1), 1993, pp. 14-19
Citations number
11
Categorie Soggetti
Biology
Journal title
International journal of peptide & protein research → ACNP
ISSN journal
03678377
Volume
42
Issue
1
Year of publication
1993
Pages
14 - 19
Database
ISI
SICI code
0367-8377(1993)42:1<14:FOP(AD>2.0.ZU;2-T
Abstract
Formation of by-products pyroglutamylglutamine diketopiperazine (5a) o r pyroglutamylasparagine diketopiperazine (5b) were observed during th e condensation of pyroglutamic acid active ester with C-protected glut aminyl(or asparaginyl)-proline derivatives. Successful synthesis of Gl p-Gln(or Asn)-Pro-derivatives is possible after coupling of Glp-Gln(or Asn)-OH with proline-derivatives. (C) Munksgaard 1993.