STUDIES ON THE CARBODIIMIDE-MEDIATED MODEL COUPLINGS OF Z-PRO-LEU-OH WITH BENZOAZA-15-CROWN-5

Authors
KULIKOV NV BASOK SS LUKYANENKO NG
Citation
Nv. Kulikov et al., STUDIES ON THE CARBODIIMIDE-MEDIATED MODEL COUPLINGS OF Z-PRO-LEU-OH WITH BENZOAZA-15-CROWN-5, International journal of peptide & protein research, 42(1), 1993, pp. 20-23
Citations number
18
Categorie Soggetti
Biology
Journal title
International journal of peptide & protein research → ACNP
ISSN journal
03678377
Volume
42
Issue
1
Year of publication
1993
Pages
20 - 23
Database
ISI
SICI code
0367-8377(1993)42:1<20:SOTCMC>2.0.ZU;2-2
Abstract
A series of model DCC-mediated couplings of Z-Pro-D-Leu-OH with benzo- 10-aza-1,4,7,13-tetraoxacyclopentadeca-2-ene were studied by high-perf ormance liquid chromatography. It was found that racemization during p reparation of N-(Z-Pro-Leu-)benzoaza-15-crown-5 is promoted by HOBT, a n additive usually reducing this process. (C) Munksgaard 1993.