AMYOTROPHIC-LATERAL-SCLEROSIS AND FRONTAL-LOBE DEMENTIA IN ALZHEIMERS-DISEASE - CASE-REPORT AND REVIEW OF THE LITERATURE

Clinicopathological data of a woman with a 3-year course of concurrent amyotrophic lateral sclerosis and dementia are presented. Dementia ha d occurred at time of onset of motor disturbances and presented as typ ical frontal lobe dementia. Pathology confirmed motor neuron disease o f amyotrophic lateral sclerosis and frontal lobe atrophy. Multiple sen ile plaques were distributed cortically and in the hippocampus, where diffuse spread of neurofibrillary tangles was seen. Hence, this Alzhei mer's dementia in a patient with sporadic amyotrophic lateral raises t he question of a possible association between the two conditions.