Hepatic segment VIII is located at the dome of the right liver lobe, n
ext to the intrahepatic inferior vena cava (IVC) and is situated betwe
en the right and the middle hepatic veins. Its close relation to the I
VC inferior medially makes liver cancer resection in this particular s
egment extremely difficult and hazardous. A personal series of 32 case
s of segment VIII resection for hepatocellular carcinoma performed dur
ing the period January 1970-May 1992 is being presented. Most resectio
ns could be performed with occlusion of the porta hepatis only but som
e cases required total hepatic vascular exclusion. Since segment VIII
is surrounded by major vessels, the extent of resection is limited in
this region. Furthermore, tumor cells are easily disseminated along th
e vascular route. The long-term results are far from ideal. One-, 3-,
and 5-year survival rates were 93.33%, 57.14%, and 28.5%, respectively
. However, eight patients in this series have survived 180, 168, 104,
78, 53, 43, 43, and 36 months, respectively, and some of them have ret
urned to work. Therefore, despite the technical difficulties involved
in segment VIII resection, it is still worthwhile adopting an aggressi
ve operative approach to this group of patients. (C) 1993 Wiley-Liss,
Inc.