OCTREOTIDE CHANGES SERUM THYROTROPIN (TSH) GLYCOISOMER DISTRIBUTION AS ASSESSED BY LECTIN CHROMATOGRAPHY IN A TSH MACROADENOMA PATIENT

Authors
FRANCIS TB SMALLRIDGE RC KANE J MAGNER JA
Citation
Tb. Francis et al., OCTREOTIDE CHANGES SERUM THYROTROPIN (TSH) GLYCOISOMER DISTRIBUTION AS ASSESSED BY LECTIN CHROMATOGRAPHY IN A TSH MACROADENOMA PATIENT, The Journal of clinical endocrinology and metabolism, 77(1), 1993, pp. 183-187
Citations number
25
Categorie Soggetti
Endocrynology & Metabolism
Journal title
The Journal of clinical endocrinology and metabolism → ACNP
ISSN journal
0021972X
Volume
77
Issue
1
Year of publication
1993
Pages
183 - 187
Database
ISI
SICI code
0021-972X(1993)77:1<183:OCST(G>2.0.ZU;2-W
Abstract
A 28-yr-old woman with hyperthyroidism due to a TSH/GH-secreting macro adenoma was treated preoperatively with octreotide to attain euthyroid al status. Lectin chromatography, performed on her immunopurified seru m TSH obtained at baseline and 1 week after 50 mug three times daily o ctreotide therapy, revealed a significant increase in ricin binding af ter octreotide. This result is consistent with increased amounts of TS H isoforms with more exposed galactose residues. Further clinical stud ies to elucidate the effects of pharmacological agents on serum TSH is oforms and TSH bioactivity are needed.