Tb. Francis et al., OCTREOTIDE CHANGES SERUM THYROTROPIN (TSH) GLYCOISOMER DISTRIBUTION AS ASSESSED BY LECTIN CHROMATOGRAPHY IN A TSH MACROADENOMA PATIENT, The Journal of clinical endocrinology and metabolism, 77(1), 1993, pp. 183-187
A 28-yr-old woman with hyperthyroidism due to a TSH/GH-secreting macro
adenoma was treated preoperatively with octreotide to attain euthyroid
al status. Lectin chromatography, performed on her immunopurified seru
m TSH obtained at baseline and 1 week after 50 mug three times daily o
ctreotide therapy, revealed a significant increase in ricin binding af
ter octreotide. This result is consistent with increased amounts of TS
H isoforms with more exposed galactose residues. Further clinical stud
ies to elucidate the effects of pharmacological agents on serum TSH is
oforms and TSH bioactivity are needed.