IMPROVEMENT OF MOUSE BETA-THALASSEMIA BY HYDROXYUREA

Citation
C. Sauvage et al., IMPROVEMENT OF MOUSE BETA-THALASSEMIA BY HYDROXYUREA, British Journal of Haematology, 84(3), 1993, pp. 492-496
Citations number
21
Categorie Soggetti
Hematology
ISSN journal
00071048
Volume
84
Issue
3
Year of publication
1993
Pages
492 - 496
Database
ISI
SICI code
0007-1048(1993)84:3<492:IOMBBH>2.0.ZU;2-0
Abstract
The present report provides evidence that hydroxyurea (HU) improves th e beta thalassaemic phenotype in mice receiving 200 mg/kg/d for 30 d. The haematocrit rose from 29 +/- 3% at day 0 to 37 +/- 4% at day 30 (P <0.05), despite myelosuppression and decreased reticulocyte counts. Th e beta minor/alpha ratio of globin chain synthesis increased from 0.78 at day 0 to 0.97 at day 30 (P<0.001). Membrane defects improved: the proportion of bound alpha chains decreased, the proportion of spectrin and ankyrin increased and red cell deformability also increased.