Ka. Salvesen et al., ROUTINE ULTRASONOGRAPHY IN-UTERO AND SUBSEQUENT HANDEDNESS AND NEUROLOGICAL DEVELOPMENT, BMJ. British medical journal, 307(6897), 1993, pp. 159-164
Objective-To examine any associations between routine ultrasonography
in utero and subsequent brain development as indicated by non-right ha
ndedness at primary school age and neurological development during chi
ldhood. Design-Follow up of 8 and 9 year old children of women who too
k part in two randomised, controlled trials of routine ultrasonography
during pregnancy. Setting-Clinics of 60 general practitioners in Norw
ay during 1979-81. Maternal and child health centres. Subjects-2161 (8
9%) of 2428 eligible singletons were followed up, partly through a que
stionnaire to their parents and partly through information from health
centres. Main outcome measures-The dominant hand of the child was ass
essed by 10 questions. Deficits in attention, motor control, and perce
ption were evaluated by five questions. Impaired neurological developm
ent during the first year of life was assessed by an abbreviated versi
on of the Denver developmental screening test. Results-The odds of non
-right handedness were higher among children who had been screened in
utero than among control children (odds ratio 1.32; 95% confidence int
erval 1.02 to 1.71). No clear differences were found between the group
s with regard to deficits in attention, motor control, and perception
or neurological development during the first year of life. Conclusion-
Our data suggest a possible association between routine ultrasonograph
y in utero and subsequent non-right handedness, whereas no association
with impaired neurological development was found. As the question on
non-right handedness was one of six initial hypotheses, the observed r
esults may be due to chance. None the less, the results suggest that t
he hypothesis may have some merit and should be tested in future studi
es.